Translational research has been defined by The National Institutes of Health (NIH) as: “the process of applying ideas, insights, and discoveries generated through basic scientific inquiry to the treatment or prevention of human disease.” The philosophy of “bench to bedside” underpins the concept of translational medicine, i.e. basic research to patient care.
Source: A review of UK health research funding (the Cooksey report) © Crown copyright 2006
The translational pathway in medicine can be simplified via the above model though it is not necessarily a linear uni-directional path. In 2006 as part of the Cooksey review, two major gaps in translation had been identified and articulated. The first gap (T1) of “…translating ideas from basic and clinical research into the development of new products and approaches to treatment of disease and illness” and the second gap (T2) of “…implementing those new products and approaches into clinical practice”.
The Office for Translational Research focusses in particular on supporting investigators bridging T1.