The following Lead Investigators and their projects have been recipients of previous CiC awards:
Disclaimer: Some project titles have been slightly modified to protect the confidentiality of the projects while preserving their general meaning and scope.
2024 – Round 15 (October submissions)
|
Treatment of bile acid diarrhoea |
|
|
A novel device for cell delivery to the brain |
|
|
Pre-clinical pharmacokinetic and toxicity studies of an ADC |
|
|
A lateral flow test for point-of-care diagnosis of Oropuche fever, a neglected tropical disease |
|
|
Astrocytic network-stabilising drug optimisation for the treatment of Parkinson's |
|
|
Manipulating mitophagy for the treatment of neurodegenerative diseases |
|
|
Microglia-targeted adoptive immunomodulatory gene therapy for Alzheimer's Disease treatment |
|
|
7T MRI in drug-resistant focal epilepsy |
|
|
Sawhney, Nipun * |
Rapid Point of Care Diagnostic Platform for Urine Culture Tests |
|
Developing explainable software for the clinical diagnosis of duodenal biopsy whole slide images |
|
|
Adaptive Radiation Therapy - Enabling Medical Image Synthesis |
|
|
Cell-free DNA analysis for the diagnosis of acute aortic dissection |
* the project received follow-on funding in this round
2023 – Round 14 (November submissions)
|
Validation of blood biomarkers for bipolar disorder |
|
|
Using ear-based wearable devices to monitor walking, mobility and other activities of daily living in subjects with balance and neurological disorders |
|
|
Multiplexing lateral flow for a ‘universal’ test for micronutrient deficiencies for maternal, infant and child health |
|
|
Brevini, Teresa |
Pre-clinical large animal study for bioengineered bile ducts |
|
Development of a point of care test for Group B Streptococcus |
|
|
Precision Medicine for Cochlear Implant Healthcare |
|
|
Therapy for reducing blood loss post-cardiac surgery |
|
|
Development of a rapid prognostication platform for acute myeloid leukaemia |
|
|
Evaluation of the activity duration of a new drug for the treatment of Parkinson’s in vivo |
|
|
Predicting prognosis in systemic lupus erythematosus to guide therapy and improve treatment outcomes |
|
|
Efficacy and safety of mitochondrial genome editing for autologous cell therapy against mitochondrial myopathies |
|
|
Microglia-targeted gene therapy for Alzheimer’s Disease treatment |
|
|
Development of a human-AI collaborative platform to enable rapid, semiautomated annotation of biopsies for transplantation |
|
|
Developing Confidence in Concept for Single-Step Bacterial Detection in Neutropenic Sepsis |
|
|
Enhancing maintenance and efficacy of CAR-T cell therapy |
|
|
Immunomodulation against neurodegenerative diseases |
|
|
Non-invasive detection of silent aspiration: Proof-of-concept clinical device development |
|
|
Liver-targeted gene therapy in ex vivo perfused human liver of patients with MNGIE |
* the project received follow-on funding in this round
2023 – Round 13 (May submissions)
|
In vivo detection of senescent cells for risk stratification, treatment adjustment and early detection of cancer |
|
|
Enabling wider application of molecular imaging of pituitary adenomas through a radiotracer |
|
|
Miniaturisation of electronics for wireless data transmission from an intraoperative aid for joint |
|
|
Inhibitor for targeting solid tumours |
|
|
Feasibility study for 7T MRI in drug-resistant focal epilepsy |
|
|
Pilot for developing methods for long-term ex-situ human heart perfusion |
|
|
Pre-clinical validation of a novel therapeutic approach for the treatment of high-risk neuroblastoma |
2022 – Round 12 (July submissions)
|
An acoustic screening device for valvular heart disease |
|
|
Vitamin K-deficiency testing in neonates |
|
|
Eva, Richard ** |
Development of gene therapy for glaucoma and optic neuropathy |
|
Improving speech perception for hearing aids |
|
|
An investigation on Cytosponge to identify patients at risk of gastric cancer |
|
|
Porcine Model Study for a Replacement Artery |
|
|
Therapy for stroke |
|
|
Generation of universal low-immunogenic cholangiocyte organoids for treatment of cholangiopathies |
|
|
Supramolecular local drug delivery for Glioblastoma |
|
|
Device for detecting aspiration during swallowing |
|
|
Use of modified RNAs against heart failure |
** the lead applicant is no longer affiliated with the University of Cambridge
2021 – Round 11 (October submissions; invitation only)
|
Integrating wireless functionality into sensors for precision orthopaedic surgery |
|
|
Prevention of viral infection |
|
|
Detecting minimal residual disease in cancer to improve patient outcomes |
2020 – Round 10 (August submissions)
|
Membranes and the reduction of clinical adhesions |
|
|
A quantitative serum metabolite ratio to predict foetal growth abnormalities |
|
|
Targeting cell death in Parkinson's disease |
|
|
Enabling wider application of molecular imaging of pituitary adenomas through a radiotracer |
|
|
Development of drugs to combat bacterial biofilms and antibiotic persisters |
|
|
Cell surface biomarkers to predict the outcome of COVID-19 upon hospital admission |
2019 – Round 9 (April submissions)
|
A system for rapid urine testing for improved delivery of antibiotics: a feasibility study |
|
|
Therapeutic targeting of chromosomal instability in cancer |
|
|
Enhancement of User Interface (UI) and User Experience (UX) of an online platform using Computerised Adaptive Testing technology to enable early assessment of mental health difficulties in secondary school students |
|
|
Henson, Frances |
An osteoarthritis treatment- a large animal proof of concept study |
|
Minimally invasive Spinal Cord Stimulator validation experiments in a human spine cadaveric model |
|
|
Development of a novel hearing computer application and modified headphone system for a sensory screening platform |
2018 – Round 8 (September submissions)
|
Beardsall, Kathryn |
NeWTS: Neonatal Wireless Transmission System |
|
A novel approach to increasing tumour immunogenicity |
|
|
Detection of placental dysfunction via secreted proteins as a novel diagnostic marker |
|
|
Development of in vivo magnetic resonance spectroscopy as a clinical diagnostic tool in brain injury patients |
|
|
Glycaemic control in type II diabetic patients |
|
|
Developing a repurposed neuroprotective drug for clinical trials |
|
|
Development of a novel polymeric trans-catheter aortic valve to improve durability in high-risk patients: proof of concept study |
|
|
Developing a novel image analysis software to assess pre-implantation kidney biopsies |
|
|
Technical validation of a patented artificial intelligence solution for the diagnosis of coeliac disease/gluten sensitivity |
** the lead applicant is no longer affiliated with the University of Cambridge
2017 – Round 7 (August submissions)
|
Development of a novel inflammation PET marker |
|
|
Mapping and modifying the spread of electrical stimulation inside the cochlea following cochlear implantation |
|
|
Detection of CJD prion infectivity using transgenic Drosophila |
|
|
Chan, Dennis ** |
Memory App for community-based detection of early Alzheimer’s Disease |
|
Targeting Glioblastoma |
|
|
Improving early prostate cancer detection using novel low-cost acoustic sensors |
|
|
Improving gene therapy protocol efficacy by modulating haematopoietic stem cell exit from quiescence |
|
|
Simple, Sensitive and High-resolution diagnostic kits for Cholera, Shigella and Typhoid |
|
|
Novel host-directed therapy in tuberculosis |
|
|
Design and build of a scaled-up device to process and obtain large quantity of lymphocytes from the spleen of a single donor |
** the lead applicant is no longer affiliated with the University of Cambridge
2016 – Round 6 (September submissions)
|
“Digi-Vis”: an all-in-one digital visual function assessment system |
|
|
Novel therapy for viral exacerbation of asthma |
|
|
Treating spinal cord injury |
|
|
Inhibiting kinases in haematological cancers |
|
|
Advanced Glioma Oncosimulator for Risk Adaptive Radiation Therapy |
|
|
A novel therapeutic strategy in Multiple Sclerosis |
|
|
Development of a Transcatheter Mitral Repair System for patients with Mitral Regurgitation |
|
|
Enhancing myelin regeneration in Multiple Sclerosis |
|
|
Zeviani, Massimo |
Assessing mitochondrial biogenesis in patients with mitochondrial myopathy |
2015 – Round 5 (April submissions)
|
Predicting plaque rupture using invasive imaging and biomechanical modelling |
|
|
CO’s immunomodulatory properties for cancer therapy |
|
|
Identification of a 'hit to lead' small molecule for the treatment of pulmonary arterial hypertension |
|
|
Development of microdialysis online-sensor technology for use in the neurocritical care of patients with acute brain injury |
|
|
Assessing the efficacy of human pluripotent stem cells for the in vitro production of platelets for transfusion |
|
|
Inhibition of RNA processing in the Plasmodium apicoplast |
|
|
RNA trans-splicing for the eradication of cells containing replicating and latent HIV |
|
|
An Alternative to Surgical Valve Replacement for Aortic Stenosis |
|
|
Analysis of the latent load of human cytomegalovirus in patients undergoing treatment with HDAC inhibitors |
* the project received follow-on funding in this round
2014 – Round 4 (September submissions)
|
A video-rate near-infrared hyperspectral endoscope for early detection of oesophageal cancer |
|
|
A novel concept for the repair of abdominal aortic aneurysms – endovascular re-lining |
|
|
Development of stapled-peptide and small-molecule inhibitors |
|
|
Improving cryopreservation of human haematopoietic stem cells and pancreatic islets |
2014 – Round 3 (April submissions)
| Cox, Timothy * |
A validated target to rescue therapeutic delivery of lysosomal enzymes |
|
Validation of genomic RNA packaging as a therapeutic target for HIV/AIDS |
|
|
Finding effective inhibitors of bacterial tripartite multidrug efflux pumps |
|
|
Maturation and characterisation of stapled peptides for Ras inhibition |
|
| Identification of novel clinical settings for drugs using a functional genomic screen for synthetic lethality |
* the project received follow-on funding in this round
2013 – Round 2 (July submissions)
|
Simple Modular Systems for the Preparation of PET Imaging Probes |
|
|
Design and in vitro characterisation of novel ‘biased’ agonists for preclinical validation of a drug target for pulmonary arterial hypertension |
|
|
New approach to the treatment of pulmonary arterial hypertension (PAH) |
|
|
Development of a novel antagonist for prostate cancer treatment |
2012 – Round 1 (December submissions)
|
A discovery platform to rescue therapeutic delivery of lysosomal enzymes in clinical applications |
|
|
Reversing immune suppression in pancreatic ductal adenocarcinoma |
|
|
New transcriptome-based biomarkers for autoimmune disease |
|
|
A regenerative therapy for Multiple Sclerosis |
|
|
Closed-loop insulin delivery in the general ward - Towards achieving optimal glucose control in hospitalised patients with type 2 diabetes |
|
|
A new approach to analgesia |
|
|
Screen for novel autophagy-modulatory kinase inhibitors |
** the lead applicant is no longer affiliated with the University of Cambridge