The following Principle Investigators and their projects have been recipients of previous CiC awards.
2022
Agrawal, Anurag |
An acoustic screening device for valvular heart disease |
Baumberg, Jeremy |
Vitamin K-deficiency testing in Neonates |
Eva, Richard |
Development of gene therapy for glaucoma and optic neuropathy |
Goehring, Tobias |
Improving speech perception for hearing aid |
di Pietro, Massimiliano |
An investigation on Cytosponge to identify patients at risk of gastric cancer |
Makaki, Athina |
Porcine Model Study of Densified Collagen Conduit as a Replacement Artery |
Murphy, Michael |
Disodium malonate as a therapy for stroke |
Saeb-Parsy, Kourosh |
Generation of universal low-immunogenic cholangiocyte organoids for treatment of cholangiopathies |
Scherman, Oren |
Supramolecular local drug delivery hydrogel depot for Glioblastoma (GB). |
Smith, Matthew |
Device for detecting aspiration during swallowing |
Catherine Wilson |
First-in-human characterisation of modRNA's regenerative potential in the failing human heart |
2021
Kar-Narayan, Sohini |
Integrating wireless functionality into conformable microfluidic force sensors for precision orthopaedic surgery |
McCaughan, Frank |
Camostat for prevention of viral infection |
Rosenfeld, Nitzan |
Detecting minimal residual disease in cancer to improve patient outcomes: accelerating implementation of novel ctDNA assays through dried blood spots |
2020
Cameron, Ruth |
Membranes and the reduction of clinical adhesions |
Campbell Smith, Gordon |
A quantitative serum metabolite ratio to predict foetal growth abnormalities |
Duce, James |
Targeting cell death by ferroptosis in Parkinson's disease |
Gurnell, Mark |
Enabling wider application of molecular imaging of pituitary adenomas through a fluorine-18 radiotracer |
Summers, David |
Development of drugs to combat bacterial biofilms and antibiotic persisters |
Weeks, Michael |
Cell surface biomarkers to predict outcome of COVID-19 upon hospital admission |
2019
Baumberg, Jeremy |
A system for rapid urine testing for improved delivery of antibiotics: a feasibility study |
Brenton, James |
Therapeutic targeting of chromosomal instability in cancer |
Ford, |
Enhancement of User Interface (UI) and User Experience (UX) of an online platform using Computerised Adaptive. Testing technology to enable early assessment of mental health difficulties in secondary school students |
Henson, Frances |
PODS-BMP7- as an ostearthitis treatment- a large animal proof of concept study |
Malliaras, George |
Minimally invasive Spinal Cord Stimulator (MI-SCS): validation experiments in human spine cadaveric model |
Rowitch, David |
Development of a novel hearing computer application and modified headphone system for the DigiScreener sensory screening platform |
2018
Beardsall, Kathryn |
NeWTS: Neonatal Wireless Transmission System |
Boyle, Louise |
A novel approach to increasing tumour immunogenicity |
Burton, Graham |
Detection of placental dysfunction using changes in glycosylation of secreted proteins as a novel diagnostic marker |
Hutchinson, Peter |
Development of in-vivo voxel-based 31P magnetic resonance spectroscopy as a clinical diagnostic tool in brain injury patients |
Ladds, Graham |
Utilising the ‘first-in-class’ small molecule positive allosteric modulators of the human GIPR to aid glycaemic control in type II diabetic patients |
Mallucci, Giovanna |
Developing the repurposed neuroprotective drug trazodone for clinical trials |
Moggridge, Geoff |
Development of a novel polymeric trans-catheter aortic valve to improve durability in high-risk patients: proof of concept study |
Pettigrew, Gavin |
Developing a novel image analysis software to assess pre-implantation kidney biopsies |
Soilleux, Elizabeth |
Technical validation of a patented artificial intelligence solution for the diagnosis of coeliac disease/ gluten sensitivity |
2017
Aigbirhio, Franklin |
Development of a novel inflammation PET marker with low binding affinity variation towards the human translocator protein |
Bance, Manohar |
Mapping and modifying spread of electrical stimulation inside the cochlea following cochlear implantation |
Bujdoso, Raymond |
Detection of CJD prion infectivity in blood and urine by bioassay in PrP transgenic Drosophila |
Chan, Dennis |
Memory App for community-based detection of early Alzheimer’s Disease (MAPP-AD) |
Cowburn, Russel |
ADNEX-GBM |
Flewitt, Andrew |
Synchronous measurement of PSA isoforms to improve early prostate cancer detection using novel low-cost acoustic sensors |
Laurenti, Elisa |
Improving gene therapy protocol efficacy by modulating haematopoietic stem cell exit from quiescence |
Mutreja, Ankur |
Simple, Sensitive and High-resolution SNP based diagnostic kits for Cholera, Shigella and Typhoid |
Nejentsev, Sergey |
Novel host-directed therapy in tuberculosis |
Saeb-Parsy, Kourosh |
Design and build of a scaled-up device to process and obtain large quantity of lymphocytes from the spleen of a single donor |
2016
Allen, Louise |
“Digi-Vis”: an all-in-one digital visual function assessment system |
Bryant , Clare |
Antagonism of TLR4 as a novel therapy for viral exacerbation of asthma |
Fawcett, James |
Repurposing 4-methylumbelliferone for spinal cord injury |
Hyvonen, Marko |
Inhibiting PH domain-mediated activation of Btk in haematological cancers |
Jena, Rajesh |
AGORA-RT: Advanced Glioma Oncosimulator for Risk Adaptive Radiation Therapy |
Jones, Joanne |
CCR5 blockade – a novel therapeutic strategy in Multiple Sclerosis |
Moggridge, Geoff |
Development of a Transcatheter Mitral Repair System for patients with Mitral Regurgitation |
Thora Karadottir, Ragnhildur |
Repurposing glutamate AMPA receptor modulators for enhancing myelin regeneration in Multiple Sclerosis |
Zeviani, Massimo |
An experimental medicine study to study the effects of nicotinamide riboside on mitochondrial biogenesis in patients with mitochondrial myopathy |
2015
Bennet, Martin |
Predicting plaque rupture using invasive imaging and biomechanical modelling |
Caldas, Carlos |
Targeted delivery of CO using artificial metalloproteins: CO’s immunomodulatory properties for cancer therapy |
Davenport, Anthony and Glen, Robert |
Identification of 'hit to lead' small molecule biased apelin receptor agonists from a potent lead series and a high throughput screen for the treatment of pulmonary arterial hypertension |
Elliot, Stephen and Hutchinson, Peter |
Development of microdialysis online-sensor technology for use in the neurocritical care of patients with acute brain injury |
Ghevaert, Cedric |
Assessing the efficacy of clinical grade banked human pluripotent stem cells for the in vitro production of platelets for transfusion |
Howe, Christopher |
Inhibition of RNA processing in the Plasmodium apicoplast |
Lever, Andrew |
RNA trans-splicing for eradication of cells containing replicating and latent HIV |
Moggridge, Geoff |
Development of a Removable Transcatheter Valve as an Alternative to Surgical Valve Replacement for Aortic Stenosis |
Sinclair, John |
Analysis of the latent load of human cytomegalovirus in patients undergoing treatment with HDACi inhibitors |
2014
Bohndiek, Sarah |
A video-rate near-infrared hyperspectral endoscope for early detection of oesophageal cancer |
Cameron, Ruth |
A novel concept for the repair of abdominal aortic aneurysms – endovascular re-lining |
Cox, Tim |
A validated targe to rescue therapeutic delivery of lysisimal enzymes |
Itzhaki, Laura |
Development of stapled-peptide and small-molecule inhibitors targeting the substrate-recognition domain of tankyrase |
Lever, Andrew |
Validation of genomic RNA packaging as a therapeutic target for HIV/AIDS |
Luisi, Ben |
Finding effective inhibitors of bacterial tripartite multidrug efflux pumps |
Mott, Helen |
Maturation and characterization of stapled peptides for Ras-RalGEF-RalA/B inhibition |
Slater, Nigel |
Improving cryopreservation of human haematopoietic stem cells and pancreatic islets |
Venkitaraman, Ashok |
Identification of novel clinical settings for BRCA2-RAD51 inhibitors using a functional genomic screen for synthetic lethality |
2013
Aigbirhio, Franklin |
Simple Modular Systems for the Preparations of PET Imaging Probes |
Davenport, Anthony |
Design and in vitro characterisation of novel ‘biased’ agonists for preclinical validation of the apelin receptor as a drug target for pulmonary arterial hypertension |
Glen, Robert |
New approach to the treatment of pulmonary arterial hypertension (PAH): Novel antagonists of the human (h)5-HT1B Receptor |
Neal, David |
Development of a novel niche-specific Androgen Receptor (AR) antagonist for prostate cancer treatment |
2012
Cox, Tim |
A discovery platform for approval drugs to rescue therapeutic delivery of lysosomal enzymes in clinical application |
Fearon, Douglas |
Reversing immune suppression in pancreatic ductal adenocarcinoma with AMD3100/Plerixafor and antibody to PD-L1 |
Franklin, Lyons |
New transcriptome-based biomarkers for autoimmune disease |
Franklin, Robin |
Identification of NCE Retinoid X Receptor gamma modulators as a regenerative therapy for Multiple Sclerosis |
Hovorka, Roman |
Closed-loop insulin delivery in the general ward - Towards achieving optimal glucose control in hospitalised patients with type 2 diabetes |
McNaughton, Peter |
A new approach to analgesia: novel antagonists of the sensitization of TRPV1 through interaction with AKAP79 |
Rubinsztein, David |
Screen for novel autophagy-modulatory kinase inhibitors |