CiC Previous Awards

Bahn, Sabine

Validation of blood biomarkers for bipolar disorder

Bance, Manohar

Using ear-based wearable devices to monitor walking, mobility and other activities of daily living in subjects with balance
and neurological disorders

Baumberg, Jeremy and Patto, Alex

Multiplexing lateral flow for a ‘universal’ test for micronutrient deficiencies for maternal, infant and child health

Brevini, Teresa and Sampaziotis, Fotios

Pre-clinical large animal study for bioengineered bile ducts

Gacciolo, Francesca and Charnock-Jones, Steve and Smith, Gordon

Development of a point of care test for Group B Streptococcus

Garcia, Charlotte and Carlyon, Bob

Precision Medicine for Cochlear Implant Healthcare: Translating the Panoramic ECAP Method from Laboratory to Clinic

Ghevaert, Cedric

Supercharged platelets as a novel therapy for reducing blood loss post-cardiac surgery

Gottgens, Bertie

Development of a rapid prognostication platform for acute myeloid leukaemia

Hastings, Nataly and Malliaras, George

Evaluation of the activity duration of a new drug for the treatment of Parkinson’s in vivo

Lyons, Paul

Predicting prognosis in systemic lupus erythematosus to guide therapy and improve treatment outcomes

Minczuk, Michal

Efficacy and safety of mitochondrial genome editing in mesoangioblasts for autologous cell therapy for mitochondrial myopathies

Paul, Arkoprovo and Kotter, Mark

Microglia-targeted adoptive immunomodulatory gene therapy for Alzheimer’s Disease treatment

Pettigrew, Gavin

Development of a human-AI collaborative platform to enable rapid, semiautomated annotation of kidney biopsies for transplantation

Rao, Akshay and Sawhney, Nipun

Developing Confidence in Concept for Single Step Bacterial Detection in Neutropenic Sepsis Using A Novel Plasmonic PCR Setup

Roychoudhuri, Rahul

Enhancing maintenance and efficacy of CAR T cell therapy using dosed delivery of quiescence factors

Rubinsztein, David

CCR5 inhibition for neurodegenerative diseases

Smith, Matthew

Non-invasive detection of silent aspiration: Proof-of-concept clinical device development

Van den Ameele, Jelle

AAV2/8-based liver-targeted gene therapy in ex-vivo perfused human liver of patients with MNGIE

Fruk, Ljiljana

In vivo detection of senescent cells for risk stratification, treatment adjustment and early detection of cancer

Gurnell, Mark

Enabling wider application of molecular imaging of pituitary adenomas through a fluorine-18 radiotracer

Kar Narayan, Sohini

Miniaturisation of electronics for wireless data transmission from an intraoperative aid for joint

Lehner, Paul

Inhibitor for targeting solid tumours

Rodgers, Chris

Feasibility study for whole-brain parallel transmit 7T MRI in drug-resistant focal epilepsy

Sinha, Sanjay

Pilot for developing methods for long term ex situ human heart perfusion

Turner, Suzanne

Pre-clinical validation of a novel therapeutic approach for the treatment of high risk neuroblastoma

Agrawal, Anurag

An acoustic screening device for valvular heart disease

Baumberg, Jeremy

Vitamin K-deficiency testing in Neonates

Eva, Richard

Development of gene therapy for glaucoma and optic neuropathy

Goehring, Tobias

Improving speech perception for hearing aid

di Pietro, Massimiliano

An investigation on Cytosponge to identify patients at risk of gastric cancer

Makaki, Athina

Porcine Model Study of Densified Collagen Conduit as a Replacement Artery

Murphy, Michael

Disodium malonate as a therapy for stroke

Saeb-Parsy, Kourosh

Generation of universal low-immunogenic cholangiocyte organoids for treatment of cholangiopathies

Scherman, Oren

Supramolecular local drug delivery hydrogel depot for Glioblastoma (GB).

Smith, Matthew

Device for detecting aspiration during swallowing

Wilson, Catherine

First-in-human characterisation of modRNA's regenerative potential in the failing human heart

Kar-Narayan, Sohini

Integrating wireless functionality into conformable microfluidic force sensors for precision orthopaedic surgery

McCaughan, Frank

Camostat for prevention of viral infection

Rosenfeld, Nitzan

Detecting minimal residual disease in cancer to improve patient outcomes: accelerating implementation of novel ctDNA assays through dried blood spots

Cameron, Ruth

Membranes and the reduction of clinical adhesions

Campbell Smith, Gordon  

A quantitative serum metabolite ratio to predict foetal growth abnormalities

Duce, James

Targeting cell death by ferroptosis in Parkinson's disease

Gurnell, Mark

Enabling wider application of molecular imaging of pituitary adenomas through a fluorine-18 radiotracer

Summers, David

Development of drugs to combat bacterial biofilms and antibiotic persisters

Weeks, Michael

Cell surface biomarkers to predict outcome of COVID-19 upon hospital admission 

Baumberg, Jeremy

A system for rapid urine testing for improved delivery of antibiotics: a feasibility study

Brenton, James

Therapeutic targeting of chromosomal instability in cancer

Ford, Tamsin

Enhancement of User Interface (UI) and User Experience (UX) of an online platform using Computerised Adaptive. Testing technology to enable early assessment of mental health difficulties in secondary school students

Henson, Frances

PODS-BMP7- as an ostearthitis treatment- a large animal proof of concept study

Malliaras, George

Minimally invasive Spinal Cord Stimulator (MI-SCS): validation experiments in human spine cadaveric model

Rowitch, David

Development of a novel hearing computer application and modified headphone system for the DigiScreener sensory screening platform

Beardsall, Kathryn

NeWTS: Neonatal Wireless Transmission System

Boyle, Louise

A novel approach to increasing tumour immunogenicity

Burton, Graham

Detection of placental dysfunction using changes in glycosylation of secreted proteins as a novel diagnostic marker

Hutchinson, Peter

Development of in-vivo voxel-based 31P magnetic resonance spectroscopy as a clinical diagnostic tool in brain injury patients

Ladds, Graham

Utilising the ‘first-in-class’ small molecule positive allosteric modulators of the human GIPR to aid glycaemic control in type II diabetic patients

Mallucci, Giovanna

Developing the repurposed neuroprotective drug trazodone for clinical trials

Moggridge, Geoff

Development of a novel polymeric trans-catheter aortic valve to improve durability in high-risk patients: proof of concept study

Pettigrew, Gavin

Developing a novel image analysis software to assess pre-implantation kidney biopsies

Soilleux, Elizabeth

Technical validation of a patented artificial intelligence solution for the diagnosis of coeliac disease/ gluten sensitivity

Aigbirhio, Franklin

Development of a novel inflammation PET marker with low binding affinity variation towards the human translocator protein

Bance, Manohar

Mapping and modifying spread of electrical stimulation inside the cochlea following cochlear implantation

Bujdoso, Raymond

Detection of CJD prion infectivity in blood and urine by bioassay in PrP transgenic Drosophila

Chan, Dennis

Memory App for community-based detection of early Alzheimer’s Disease (MAPP-AD)

Cowburn, Russel

ADNEX-GBM

Flewitt, Andrew

Synchronous measurement of PSA isoforms to improve early prostate cancer detection using novel low-cost acoustic sensors

Laurenti, Elisa

Improving gene therapy protocol efficacy by modulating haematopoietic stem cell exit from quiescence

Mutreja, Ankur

Simple, Sensitive and High-resolution SNP based diagnostic kits for Cholera, Shigella and Typhoid

Nejentsev, Sergey

Novel host-directed therapy in tuberculosis

Saeb-Parsy, Kourosh

Design and build of a scaled-up device to process and obtain large quantity of lymphocytes from the spleen of a single donor

Allen, Louise

“Digi-Vis”: an all-in-one digital visual function assessment system

Bryant , Clare

Antagonism of TLR4 as a novel therapy for viral exacerbation of asthma

Fawcett, James

Repurposing 4-methylumbelliferone for spinal cord injury

Hyvonen, Marko

Inhibiting PH domain-mediated activation of Btk in haematological cancers

Jena, Rajesh

AGORA-­RT: Advanced Glioma Oncosimulator for Risk Adaptive Radiation Therapy

Jones, Joanne

CCR5 blockade – a novel therapeutic strategy in Multiple Sclerosis

Moggridge, Geoff

Development of a Transcatheter Mitral Repair System for patients with Mitral Regurgitation

Thora Karadottir, Ragnhildur

Repurposing glutamate AMPA receptor modulators for enhancing myelin regeneration in Multiple Sclerosis

Zeviani, Massimo

 An experimental medicine study to study the effects of nicotinamide riboside on mitochondrial biogenesis in patients with mitochondrial myopathy

Bennet, Martin

Predicting plaque rupture using invasive imaging and biomechanical modelling

Caldas, Carlos

Targeted delivery of CO using artificial metalloproteins: CO’s immunomodulatory properties for cancer therapy

Davenport, Anthony and Glen, Robert 

Identification of 'hit to lead' small molecule biased apelin receptor agonists from a potent lead series and a high throughput screen for the treatment of pulmonary arterial hypertension

Elliot, Stephen and Hutchinson, Peter

Development of microdialysis online-sensor technology for use in the neurocritical care of patients with acute brain injury

Ghevaert, Cedric

Assessing the efficacy of clinical grade banked human pluripotent stem cells for the in vitro production of platelets for transfusion

Howe, Christopher

Inhibition of RNA processing in the Plasmodium apicoplast

Lever, Andrew

RNA trans-splicing for eradication of cells containing replicating and latent HIV

Moggridge, Geoff

Development of a Removable Transcatheter Valve as an Alternative to Surgical Valve Replacement for Aortic Stenosis

Sinclair, John

Analysis of the latent load of human cytomegalovirus in patients undergoing treatment  with HDACi inhibitors

Bohndiek, Sarah

A video-rate near-infrared hyperspectral endoscope for early detection of oesophageal cancer

Cameron, Ruth

A novel concept for the repair of abdominal aortic aneurysms – endovascular re-lining

Cox, Tim

A validated targe to rescue therapeutic delivery of lysisimal enzymes

Itzhaki, Laura

Development of stapled-peptide and small-molecule inhibitors targeting the substrate-recognition domain of tankyrase

Lever, Andrew

Validation of genomic RNA packaging as a therapeutic target for HIV/AIDS

Luisi, Ben

 Finding effective inhibitors of bacterial tripartite multidrug efflux pumps

Mott, Helen

Maturation and characterization of stapled peptides for Ras-RalGEF-RalA/B inhibition

Slater, Nigel

Improving cryopreservation of human haematopoietic stem cells and pancreatic islets

Venkitaraman, Ashok

 Identification of novel clinical settings for BRCA2-RAD51 inhibitors using a functional genomic screen for synthetic lethality

Aigbirhio, Franklin

Simple Modular Systems for the Preparations of PET Imaging Probes

Davenport, Anthony

Design and in vitro characterisation of novel ‘biased’ agonists for preclinical validation of the apelin receptor as a drug target for pulmonary arterial hypertension

Glen, Robert

New approach to the treatment of pulmonary arterial hypertension (PAH): Novel antagonists of the human (h)5-HT1B Receptor

Neal, David

Development of a novel niche-specific Androgen Receptor (AR) antagonist for prostate cancer treatment

Cox, Tim

A discovery platform for approval drugs to rescue therapeutic delivery of lysosomal enzymes in clinical application

Fearon, Douglas

Reversing immune suppression in pancreatic ductal adenocarcinoma with AMD3100/Plerixafor and antibody to PD-L1

Franklin, Lyons

New transcriptome-based biomarkers for autoimmune disease

Franklin, Robin

Identification of NCE Retinoid X Receptor gamma modulators as a regenerative therapy for Multiple Sclerosis

Hovorka, Roman 

Closed-loop insulin delivery in the general ward - Towards achieving optimal glucose control in hospitalised patients with type 2 diabetes

McNaughton, Peter

A new approach to analgesia: novel antagonists of the sensitization of TRPV1 through interaction with AKAP79

Rubinsztein, David

Screen for novel autophagy-modulatory kinase inhibitors